Preliminary results of synchronous acquired PET/MRI for viability assessment in patients with reduced cardiac function prior revascularization

Methods We wanted to assess the interrater reliability of viability assessment in a hybrid PET/MR system, to assess if it could have additional value for patients prior revascularization. Therefore we examined 9 patients, scheduled for viability assessment by PET as a simultaneous PET/MR examination (mMR Biograph, Siemens, Erlangen, Germany). All patients were examined 50-60’after i.v. application of a mean activity of 319 MBq. The MRI protocol consisted of Cine SSFP sequences in 2 chamber, 4 chamber and short axis orientation (SA). For late enhancement assessment phase sensitive inversion recovery sequences (PSIR) in SA were acquired 10-15 minutes after administration of 0.15 mmol/kg body weight Gadobutrol (Gadovist, Bayer Healthcare, Berlin, Germany). 7 patients got 50g glucose and a individual dose of insulin, depending on blood glucose level. In 2 patients suffering from type 2 diabetes mellitus a standardized glucose clamp was performed. One patient got